The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 27, 2018

Filed:

Feb. 24, 2012
Applicants:

Linda Vahdat, Wilton, CT (US);

Shahin Rafii, Great Neck, NY (US);

Rakhi Naik, Columbia, MD (US);

Maureen Lane, Mt. Vernon, NY (US);

Vivek Mittal, Greenlawn, NY (US);

Inventors:

Linda Vahdat, Wilton, CT (US);

Shahin Rafii, Great Neck, NY (US);

Rakhi Naik, Columbia, MD (US);

Maureen Lane, Mt. Vernon, NY (US);

Vivek Mittal, Greenlawn, NY (US);

Assignee:

Cornell University, Ithaca, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12N 5/00 (2006.01); G01N 33/68 (2006.01); G01N 33/569 (2006.01); G01N 33/574 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C07K 16/2863 (2013.01); G01N 33/56966 (2013.01); G01N 33/574 (2013.01); G01N 2800/52 (2013.01); G01N 2800/54 (2013.01);
Abstract

Methods of determining cancer progression or cancer relapse in a subject at risk for cancer progression or cancer relapse, the methods comprising: obtaining a sample from said subject; measuring the level of VEGFR1hematopoietic progenitor cells (HPCs) and/or VEGFR2endothelial progenitor cells (EPCs) in said sample; and taking additional samples and conducting additional measurements of HPCs and/or EPCs at one or more later time points. From the measurements, it can be determined whether there is a surge in the level of HPCs and/or EPCs in at least one later measurement, relative to an earlier measurement. A surge in the level of HPCs and/or EPCs indicates increased risk of progression or relapse of said subject's cancer.


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