The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Jul. 27, 2015
Roche Diabetes Care, Inc., Indianapolis, IN (US);
Marco Bocola, Aachen, DE;
Hartmut Duefel, Schlehdorf, DE;
Erik Uwe Arango Gutierrez, Aachen, DE;
Dieter Heindl, Munich, DE;
Thomas Meier, Munich, DE;
Hemanshu Mundhada, Lyngby, DK;
Ulrich Schwaneberg, Kelmis-Hergenrath, BE;
Michael Tacke, Munich, DE;
Roche Diabetes Care, Inc., Indianapolis, IN (US);
Abstract
Novel glucose oxidase (GOx) variants are disclosed that have the substitutions of T30V and I94V set forth in SEQ ID NO:1, and additionally at least one further amino acid substitution in the enzyme sequence in any of the positions S53; A137; A173; A332; F414 and V560. The GOx variants herein exhibit specificity for glucose and significantly reduced oxygen consumption rates and/or increased enzyme activity for electron mediators other than oxygen. Also provided are assay devices incorporating at least one of the GOx variants herein for improved blood glucose measurements.