The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Apr. 16, 2012
John Fulkerson, Silver Spring, MD (US);
Michael Brennan, Rockville, MD (US);
Kamalakannan Velmurugan, Rockville, MD (US);
Camille Locht, Brussels, BE;
John Fulkerson, Silver Spring, MD (US);
Michael Brennan, Rockville, MD (US);
Kamalakannan Velmurugan, Rockville, MD (US);
Camille Locht, Brussels, BE;
Aeras, Rockville, MD (US);
Institut National De La Sante Et De La Recherche Medicale (Inserm), Paris, FR;
Abstract
Recombinant(rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.