The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Feb. 17, 2015
The Hospital for Sick Children, Toronto, CA;
Vanderbilt University, Nashville, TN (US);
Roman Melnyk, Oakville, CA;
Zhifen Zhang, Toronto, CA;
John Tam, Markham, CA;
Dana Borden Lacy, Nashville, TN (US);
Stacey A. Seeback, Greenbier, TN (US);
Nicole M. Chumbler, Stockbridge, TN (US);
THE HOSPITAL FOR SICK CHILDREN, Toronto, Ontario, CA;
VANDERBILT UNIVERSITY, Nashville, TN (US);
Abstract
is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine tothat can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modifiedtoxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of, but toxicity is reduced.