The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Jun. 02, 2014
Applicant:
Medivation Technologies Llc, San Francisco, CA (US);
Inventors:
Bing Wang, San Jose, CA (US);
Daniel Chu, Santa Clara, CA (US);
Yongbo Liu, Shanghai, CN;
Quan Jiang, Shanghai, CN;
Lei Lu, Ningbo, CN;
Assignee:
Medivation Technologies LLC, San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/06 (2006.01); C07D 249/08 (2006.01); C07D 401/04 (2006.01); C07D 403/06 (2006.01); C07D 471/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/06 (2013.01); C07D 249/08 (2013.01); C07D 401/04 (2013.01); C07D 403/06 (2013.01); C07D 471/06 (2013.01);
Abstract
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.