The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Nov. 29, 2013
Centaurus Biopharma Co., Ltd., Beijing, CN;
Yongxin Han, Beijing, CN;
Rong Yu, Beijing, CN;
Zanping Wang, Beijing, CN;
Zhi Liang, Beijing, CN;
Quan Hu, Beijing, CN;
Li Zhu, Beijing, CN;
Yuandong Hu, Beijing, CN;
Yinghui Sun, Beijing, CN;
Na Zhao, Beijing, CN;
Yong Peng, Beijing, CN;
Xiaofeng Zhai, Beijing, CN;
Hong Luo, Beijing, CN;
Dengming Xiao, Beijing, CN;
Centaurus BioPharma Co., Ltd., Beijing, CN;
Abstract
The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.