The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Mar. 07, 2014
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Liaoning, CN;
Jilin Asymchem Laboratories Co., Ltd., Jilin, CN;
Hao Hong, Tianjin, CN;
James Gage, Tianjin, CN;
Jiuyuan Li, Tianjin, CN;
Litao Shen, Tianjin, CN;
Lei Zhang, Tianjin, CN;
Changming Dong, Tianjin, CN;
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Liaoning, CN;
Jilin Asymchem Laboratories Co., Ltd., Jilin, CN;
Abstract
Provided are an intermediate compound for preparing rosuvastatin calcium and a preparation method of the rosuvastatin calcium. The method comprises: using the foregoing intermediate compound as a raw material, and subjecting the raw material to a step of Wittig reaction, a step of protecting group removal and hydrolysis and a step of calcium salt formation, so as to obtain the rosuvastatin calcium. The product, which is prepared from the intermediate compound, can be substantially enhanced in stereoselectivity and also notably improved in purity and yield; in addition, the method for preparing rosuvastatin calcium from the intermediate compound is simple, convenient and low in cost.