The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Mar. 21, 2013
Zeochem Ag, Ruti, CH;
Nicola Forrer, Glattpark, CH;
Mandy Erdmann, Uznach, CH;
David Gétaz, Ollon, CH;
Massimo Morbidelle, Zürich, CH;
Susanna Bernardi, Potenza Picena, CH;
Rushd Khalaf, Zürich, CH;
ZEOCHEM AG, Ruti, CH;
Abstract
A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/mto 0.8 μmol/mreferred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m. Such material and suitable purification conditions for active pharmaceutical ingredients (APIs) like peptides can be evaluated by (a) determining the isoelectric point (pI) of the API of interest, (b) choosing a pH in a range where the solid phase material is stable, (c) determining the difference pI−pH and (d) if the difference pI−pH is positive, choosing an anion exchange (AIEX) material, or if the difference pI−pH is negative, choosing an cation exchange (CIEX) material.