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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9925306 B1

PDFFull Text
Date of Patent:
Mar. 27, 2018

Filed:

Jan. 09, 2017

Hyaluronic acid-calcium phosphate composite for growth factor support and method for producing same

Applicant:

Bioalpha Inc., Seoul, KR;

Inventors:

Jung Ju Kim, Gyeonggi-Do, KR;

Su Hyun Jung, Jeollabuk-Do, KR;

Hyun Seung Ryu, Gyeonggi-Do, KR;

Jun Hyuk Seo, Gyeonggi-Do, KR;

Assignee:

Bioalpha Inc., Seoul, KR;

Attorney:

Rosenberg, Klein & Lee

Primary Examiner:

Ernst V Arnold

Int. Cl.
CPC ...
A61L 27/46 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61L 27/20 (2006.01); C08L 5/08 (2006.01); A61L 27/12 (2006.01); A61L 27/58 (2006.01); C01B 25/32 (2006.01); C08K 3/32 (2006.01); C08K 7/18 (2006.01);
U.S. Cl.
CPC ...
A61L 27/46 (2013.01); A61L 27/12 (2013.01); A61L 27/20 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); C01B 25/327 (2013.01); C08K 3/32 (2013.01); C08K 7/18 (2013.01); C08L 5/08 (2013.01); A61L 2300/414 (2013.01); A61L 2430/02 (2013.01); C01P 2004/32 (2013.01); C01P 2004/61 (2013.01); C08K 2003/325 (2013.01); C08K 2201/005 (2013.01);
Abstract

The present invention relates to a carrier for growth factor related to regeneration of bone tissues that is capable of arbitrarily controlling the delivery rate of growth factors related to bone regeneration and thus especially applicable to a bone void filler in the fields of the dental or orthopedic applications. The carrier for controlling the delivery rate of the growth factor in the present invention is composed of a hyaluronic acid hydrogel having a distribution of interconnected pores and a calcium phosphate microsphere being distributed in the pores of the hyaluronic acid hydrogel. The calcium phosphate microsphere having a porosity suitable for delivery of the growth factor is positioned into the pores of the cross-linked hyaluronic acid hydrogel to complete the carrier.

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