The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Apr. 11, 2016
Wisconsin Alumni Research Foundation, Madison, WI (US);
Jamey Paul Weichert, Fitchburg, WI (US);
Chorom Pak, Madison, WI (US);
Benjamin Titz, Madison, WI (US);
Fotis Asimakopoulos, Madison, WI (US);
Roberta Marino, Cordova, TN (US);
Mario Otto, Fitchburg, WI (US);
Kevin R. Kozak, Janesville, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
It is disclosed herein that that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells. The alkylphophocholine analogs are compounds having the formula: or salts thereof, wherein n is an integer from 12 to 24; and Ris —NH, —NHX, —NHX, or —NHX, wherein each X is independently —CHor —CH. The compounds can be used to treat multiple myeloma or to detect multiple myeloma. In therapeutic treatment, Rincludes a radionuclide that locally delivers therapeutic dosages of radiation to the multiple myeloma tumors cells that preferentially take up the compound. In detection/imaging applications, Rincludes a detection moiety, such as a fluorophore or a radiolabel.