The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Mar. 28, 2013
Applicant:
Bracco Imaging S.p.a., Milan, IT;
Inventors:
Pernille Rose Jensen, Vaerlose, DK;
Magnus Karlsson, Malmo, SE;
Mathilde H. Lerche, Frederiksberg C, DK;
Assignee:
BRACCO IMAGING S.P.A., Milan, IT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); C07C 231/12 (2006.01);
U.S. Cl.
CPC ...
A61K 49/10 (2013.01); C07C 231/12 (2013.01);
Abstract
Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.