The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Jan. 26, 2015
Applicant:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Inventors:
S. Ananth Karumanchi, Chestnut Hill, MA (US);
Sharon Maynard, Emmaus, PA (US);
Vikas P. Sukhatme, Newton, MA (US);
Assignee:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 38/18 (2006.01); G01N 33/74 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); C12Q 1/48 (2006.01); A61K 31/522 (2006.01); C07K 16/12 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C12N 15/113 (2010.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 31/522 (2013.01); A61K 38/1866 (2013.01); A61K 38/1891 (2013.01); A61K 45/06 (2013.01); C07K 16/1217 (2013.01); C07K 16/18 (2013.01); C07K 16/2863 (2013.01); C07K 16/40 (2013.01); C12N 15/1138 (2013.01); C12Q 1/485 (2013.01); G01N 33/689 (2013.01); G01N 33/6893 (2013.01); G01N 33/74 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); G01N 2500/00 (2013.01); G01N 2800/368 (2013.01);
Abstract
Disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the treatment of pre-eclampsia or eclampsia.