The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2018
Filed:
Mar. 04, 2014
Applicant:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventors:
Jane Yu, Cincinnati, OH (US);
Chenggang Li, Maineville, OH (US);
Assignee:
BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/616 (2006.01); A61K 31/192 (2006.01); A61K 31/436 (2006.01); A61K 31/18 (2006.01); A61K 45/06 (2006.01); A61K 31/12 (2006.01); A61K 31/196 (2006.01); A61K 31/365 (2006.01); A61K 31/405 (2006.01); A61K 31/415 (2006.01); A61K 31/42 (2006.01);
U.S. Cl.
CPC ...
A61K 31/616 (2013.01); A61K 31/12 (2013.01); A61K 31/18 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/365 (2013.01); A61K 31/405 (2013.01); A61K 31/415 (2013.01); A61K 31/42 (2013.01); A61K 31/436 (2013.01); A61K 45/06 (2013.01);
Abstract
Embodiments disclosed herein provide compositions and methods for treating lymphangioleiomyomatosis (LAM) comprising inhibiting COX overexpression and prostaglandin over production by administering at least one COX inhibitor and/or prostaglandin biosynthetic pathway inhibitors. Lymphangioleiomyomatosis (LAM) is a rare lung disease. Some LAM occurances are associated with mutations in the tuberous sclerosis complex (TSC) locus. LAM occurs almost exclusively in women, usually of childbearing age.