The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Aug. 26, 2016
Novartis Ag, Basel, CH;
Massachusetts Institute of Technology, Cambridge, MA (US);
Naresh Chennamsetty, Cambridge, MA (US);
Bernhard Helk, Basel, CH;
Bernhardt Trout, Cambridge, MA (US);
Veysel Kayser, Cambridge, MA (US);
Vladimir Voynov, Cambridge, MA (US);
Novartis AG, Basel, CH;
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.