The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Dec. 04, 2014
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Raghu Kalluri, Houston, TX (US);
Sónia Melo, Porto, PT;
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); A61K 35/12 (2015.01); C12Q 1/68 (2018.01); A61K 9/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57488 (2013.01); A61K 35/12 (2013.01); C12Q 1/6886 (2013.01); A61K 9/5068 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/705 (2013.01);
Abstract
The present invention provides that exosomes from human body fluid samples contain double stranded genomic DNA that spans all chromosomes and may be used to determine the mutation status of genes of interest in diseases, such as cancer. Furthermore, the present invention provides the use of exosomes to produce therapeutic proteins and for their use in therapy as well as the detection of cancer cell-derived exosomes to diagnose cancer and monitor therapeutic response.