The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Nov. 09, 2012
Applicant:
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Allison Berger, Arlington, MA (US);
Nibedita Chattopadhyay, Wellesley, MA (US);
Erik M. Koenig, North Reading, MA (US);
Assignee:
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); A61K 31/69 (2006.01); A61K 38/06 (2006.01); G01N 33/50 (2006.01); G06F 19/00 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/69 (2013.01); A61K 38/06 (2013.01); G01N 33/5011 (2013.01); G06F 19/328 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Disclosed are markers associated with sensitivity to treatment with proteasome inhibitors. Sensitivity is observed when RAS gene is wild type in tumor cells. Compositions and methods are further provided to assess markers of marker genes to predict outcome of treatment using proteasome inhibitors to patients having a solid tumor, such as a lung tumor or a colon tumor.