The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Oct. 26, 2016
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Bryan Irving, San Francisco, CA (US);
Henry Chiu, San Francisco, CA (US);
Heather Maecker, Palo Alto, CA (US);
Sanjeev Mariathasan, Millbrae, CA (US);
Sophie M. Lehar, Montara, CA (US);
Yan Wu, Foster City, CA (US);
Jeanne Cheung, San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 31/7068 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/10 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2827 (2013.01); A61K 31/7068 (2013.01); A61K 39/00 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/1063 (2013.01); C07K 16/22 (2013.01); C07K 16/28 (2013.01); C07K 16/30 (2013.01); C07K 16/3046 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/71 (2013.01); C07K 2317/73 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.