The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 20, 2018

Filed:

Mar. 17, 2015
Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Paul J. Hergenrother, Champaign, IL (US);

Elizabeth I. Parkinson, Champaign, IL (US);

Joseph S. Bair, Millica Hill, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4748 (2006.01); C07D 498/18 (2006.01); C07D 498/16 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/00 (2006.01); A61K 9/12 (2006.01); A61K 9/06 (2006.01); A61K 31/4745 (2006.01);
U.S. Cl.
CPC ...
C07D 498/16 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 9/12 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 31/4745 (2013.01);
Abstract

Compounds that specifically kill fluoroquinolone (FQ) resistant bacteria have been developed and are described herein. The FQs are the most commonly prescribed antibiotics to adults in the U.S. and thus are extremely important drugs. However, bacterial resistant to these drugs is now ubiquitous in some of the most common and deadly Gram-positive pathogens, including methicillin-resistant(MRSA) and vancomycin-resistant enterococci (VRE). Indeed, FQs are no longer indicated for treatment of MRSA and VRE infections because of such resistance. The compounds have specific and potent activity versus MRSA and VRE.


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