The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Jul. 08, 2015
Applicant:
Zentiva K.s., Prague, CZ;
Inventors:
Assignee:
Zentiva k.s., Prague, CZ;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/20 (2006.01); C07D 211/70 (2006.01); C07D 295/096 (2006.01); C07C 323/00 (2006.01);
U.S. Cl.
CPC ...
C07D 295/096 (2013.01); C07C 323/00 (2013.01);
Abstract
The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)phenyl)piperazine of formula (I) or its salt comprises a reaction of 2-(2,4-dimethylphenyl-sulphanyl)benzeneamine of formula (XI), wherein Me is methyl, with a suitable precursor of formation of piperazine ring of formula (XII), wherein LG is a leaving group and R is hydrogen or a protective group, in a suitable organic solvent, wherein the reaction is carried out without presence of a base in a neutral or acidic environment. (Formulae (I), (XI), (XII))