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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9919060 B1

PDFFull Text
Date of Patent:
Mar. 20, 2018

Filed:

Feb. 06, 2017

Treatment or prophylaxis of proliferative conditions

Applicant:

University Court of the University of Dundee, Dundee, GB;

Inventors:

Steven Albert Everett, Menlo Park, CA (US);

Saraj Ulhaq, Dundee, GB;

Assignee:

University Court of the University of Dundee, Dundee, GB;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Ganapathy Krishnan

Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 31/37 (2006.01); A61K 31/52 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/428 (2006.01); A61K 31/513 (2006.01); A61K 31/665 (2006.01); A61K 47/54 (2017.01); C07D 491/22 (2006.01); C07D 487/04 (2006.01); C07D 417/12 (2006.01); C07D 409/12 (2006.01); C07D 407/12 (2006.01); C07D 405/14 (2006.01); C07D 405/12 (2006.01); C07D 405/04 (2006.01); C07D 311/18 (2006.01); C07D 311/16 (2006.01); C07D 307/80 (2006.01); A61K 31/664 (2006.01); A61K 31/4184 (2006.01); A61K 31/352 (2006.01);
U.S. Cl.
CPC ...
A61K 47/545 (2017.08); A61K 31/343 (2013.01); A61K 31/352 (2013.01); A61K 31/37 (2013.01); A61K 31/381 (2013.01); A61K 31/4184 (2013.01); A61K 31/428 (2013.01); A61K 31/513 (2013.01); A61K 31/52 (2013.01); A61K 31/664 (2013.01); A61K 31/665 (2013.01); C07D 307/80 (2013.01); C07D 311/16 (2013.01); C07D 311/18 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01); C07D 491/22 (2013.01);
Abstract

The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.

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