The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 20, 2018

Filed:

Oct. 31, 2013
Applicants:

Amgen Research (Munich) Gmbh, Munich, DE;

Takeda Gmbh, Constance, DE;

Inventors:

Thomas Urbig, Munich, DE;

Thomas Boehm, Munich, DE;

Wolfram Steinhilber, Stockach, DE;

Michael Molhoj, Munich, DE;

Assignees:

Amgen Research (Munich) GmbH, Munich, DE;

Takeda GmbH, Konstanz, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/26 (2006.01); A61K 47/18 (2017.01); A61K 39/395 (2006.01); C07K 16/24 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/26 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 39/39591 (2013.01); A61K 47/183 (2013.01); C07K 16/24 (2013.01); C07K 16/243 (2013.01); A61K 2039/505 (2013.01);
Abstract

The present invention relates to aqueous formulations comprising a compound neutralizing GM-CSF in concentrations of at least about 20 mg/ml, a tonicity modifier and a buffer, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of long-term storage. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.


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