The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2018
Filed:
Jan. 15, 2015
Applicants:
Vib Vzw, Ghent, BE;
Universiteit Gent, Ghent, BE;
Inventors:
Peter Vandenabeele, Sint-Amandsberg, BE;
Anje Cauwels, Merelbeke, BE;
Tom Vandenberghe, Haasdonk, BE;
Assignees:
VIB VZW, Ghent, BE;
UNIVERSITEIT GENT, Ghent, BE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 38/17 (2006.01); C07K 16/24 (2006.01); A61K 38/20 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 38/17 (2013.01); A61K 38/1793 (2013.01); A61K 38/20 (2013.01); C07K 16/244 (2013.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention relates to the inactivation of interleukin-1 and interleukin-18 signaling in treatment of inflammation and septic shock. More specifically, it relates to a sequential or simultaneous application of both an interleukin-1 receptor antagonist and an interleukin-18 antibody. In one preferred embodiment, a combination treatment of an IL-1 receptor antagonist and an IL-18 antibody is used.