The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 20, 2018

Filed:

Apr. 26, 2017
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Helen M. Blau, Stanford, CA (US);

Andrew Tri Van Ho, Stanford, CA (US);

Adelaida R. Palla, Stanford, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/34 (2015.01); A61K 31/5575 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 31/5575 (2013.01); A61K 35/34 (2013.01); C12N 5/0658 (2013.01); C12N 2501/02 (2013.01);
Abstract

Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.


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