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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9918985 B1

PDFFull Text
Date of Patent:
Mar. 20, 2018

Filed:

Jul. 26, 2017

Compounds and their use as bace inhibitors

Applicant:

Astrazeneca Ab, Sodertalje, SE;

Inventors:

Gabor Csjernyik, Macclesfield, GB;

Sofia Karlstrom, Macclesfield, GB;

Annika Kers, Macclesfield, GB;

Karin Kolmodin, Macclesfield, GB;

Martin Nylof, Sodertalje, SE;

Liselotte Ohberg, Macclesfield, GB;

Laszlo Rakos, Macclesfield, GB;

Lars Sandberg, Macclesfield, GB;

Fernando Sehgelmeble, Macclesfield, GB;

Peter Soderman, Macclesfield, GB;

Britt-Marie Swahn, Macclesfield, GB;

Stefan Von Berg, Molndal, SE;

Assignee:

ASTRAZENECA AB, Sodertalje, SE;

Attorney:

White & Case LLP

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/497 (2006.01); C07D 235/02 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 491/107 (2006.01); C07D 491/20 (2006.01); A61K 45/06 (2006.01); A61K 31/4184 (2006.01); A61K 31/4188 (2006.01); A61K 31/506 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
A61K 31/497 (2013.01); A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 235/02 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01); A61K 2300/00 (2013.01);
Abstract

The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ('mild cognitive impairment'), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

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