The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Jul. 31, 2014
Council of Scientific & Industrial Research, New Delhi, IN;
Asha Syamakumari, Pune, IN;
Senthil Kumar, Pune, IN;
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, New Delhi, IN;
Abstract
The present invention provide water soluble polyfluorenes functionalized with glucuronic acid useful in sensing bilirubin in aqueous medium and process for preparation thereof. The invention further deals with detecting bilirubin in human serum samples in the range from normal (<25 μmol/L˜1.2 mg/dL) human bilirubin level to jaundiced bilirubin level (>50 μmol/L˜2.5 mg/dL).This is a fluorescence turn-off mode of detection where blue fluorescence of polymer quenches and becomes colorless. The water soluble polyfluorenes functionalized with glucuronic acid can detect free bilirubin in the range from 1×10M to 1×10M moles in aqueous and buffer media as a change in the fluorescence signal.