The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Nov. 06, 2015
Long Liu, Wuxi, CN;
Jian Chen, Wuxi, CN;
Guocheng Du, Wuxi, CN;
Jianghua LI, Wuxi, CN;
Yanfeng Liu, Wuxi, CN;
Hannes Link, Zurich, CH;
Uwe Sauer, Zurich, CH;
Long Liu, Wuxi, CN;
Jian Chen, Wuxi, CN;
Guocheng Du, Wuxi, CN;
Jianghua Li, Wuxi, CN;
Yanfeng Liu, Wuxi, CN;
Hannes Link, Zurich, CH;
Uwe Sauer, Zurich, CH;
Jiangnan University, Wuxi, JS, CN;
Abstract
The present invention provides a method for enhancing N-acetylglucosamine production by usage of a recombinantwith a glcK knockout. This invention enhanced the production of GlcNAc by knocking out the glcK gene which encodes a glucokinase, thus eliminating the GlcNAc phosphorylation to GlcNAc-6-P. The specific growth rate and content of GlcNAc in the supernatant of the recombinantwith the glcK knockout were 0.15 hand 3.0 g/L, respectively, which were 2.32 times and 2.14 times of those of the control strain without glcK knockout. The recombinantof the present invention would be potentially useful for industrial production of GlcNAc.