The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Mar. 03, 2016
Applicant:
Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);
Inventors:
Austin L. Gurney, San Francisco, CA (US);
Aaron K. Sato, Burlingame, CA (US);
Assignee:
ONCOMED PHARMACEUTICALS, INC., Redwood City, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/22 (2006.01); A61K 39/395 (2006.01); A61K 51/10 (2006.01); A61K 45/06 (2006.01); C07K 16/18 (2006.01); C07K 16/46 (2006.01); C12N 15/00 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 51/1021 (2013.01); C07K 16/18 (2013.01); C07K 16/468 (2013.01); A61K 47/6845 (2017.08); A61K 2039/505 (2013.01); C07K 2317/20 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/64 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C12N 15/00 (2013.01);
Abstract
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.