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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9914735 B1

PDFFull Text
Date of Patent:
Mar. 13, 2018

Filed:

Mar. 12, 2015

Heteroaryl syk inhibitors

Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Georg Dahmann, Biberach, DE;

Matthias Hoffmann, Mittelbiberach, DE;

Jasna Klicic, Geneva, CH;

David James Lamb, Mittelbiberach, DE;

Clive McCarthy, Wantage, GB;

Spencer Charles R. Napier, Abingdon, GB;

Karen Parrish, Abingdon, GB;

John Scott, Abingdon, GB;

Jennifer L. Swantek Fitzgerald, Ridgefield, CT (US);

Edward Walker, Didcot, GB;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Marc Began

Philip I. Datlow

Primary Examiner:

Pancham Bakshi

Int. Cl.
CPC ...
A61K 31/4184 (2006.01); C07D 487/04 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01); A61K 31/416 (2006.01); A61K 31/427 (2006.01); A61K 31/437 (2006.01); A61K 31/444 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/416 (2013.01); A61K 31/4184 (2013.01); A61K 31/427 (2013.01); A61K 31/437 (2013.01); A61K 31/444 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The invention relates to new substituted heteroaryls of formula (1), wherein A is selected from the group consisting of N and CH, D is CH, E is selected from the group consisting of C and N, T is C, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R, M and Rare defined according to claim, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.

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