The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 13, 2018

Filed:

Sep. 27, 2013
Applicants:

Ignyta, Inc., San Diego, CA (US);

Cancer Research Technology Limited, London, GB;

Inventors:

Henry J. Breslin, Lansdale, PA (US);

Bruce D. Dorsey, Ambler, PA (US);

Benjamin J Dugan, Glen Mills, PA (US);

Katherine M. Fowler, Caversham, GB;

Robert L Hudkins, Chester Springs, PA (US);

Eugen F. Mesaros, Wallingford, PA (US);

Nathaniel J. T. Monck, Ascot, GB;

Emma L. Morris, Biggleswade, GB;

Ikeoluwa Olowoye, Hemel Hempstead, GB;

Gregory R. Ott, Media, PA (US);

Gregoire A. Pave, London, GB;

Jonathan R. Roffey, Reading, GB;

Christelle N. Soudy, London, GB;

Ming Tao, Maple Glen, PA (US);

Craig A. Zificsak, Downingtown, PA (US);

Allison L. Zulli, Wayne, PA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); C07D 493/08 (2006.01); C07D 498/04 (2006.01); C07F 9/6584 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 493/08 (2013.01); C07D 498/04 (2013.01); C07D 519/00 (2013.01); C07F 9/6584 (2013.01);
Abstract

The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C ('aPKC') inhibitory activity, and may be used to treat proliferative disorders.


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