The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Mar. 29, 2013
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Zaneta Nikolovska-Coleska, Ann Arbor, MI (US);
Naval Bajwa, Lafayette, IN (US);
Chenzhong Liao, Anhui, CN;
Lei Miao, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/06 (2006.01); C07D 409/14 (2006.01); C07D 405/14 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 307/92 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/06 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 307/92 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01);
Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.