IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9914719 B1

PDFFull Text
Date of Patent:
Mar. 13, 2018

Filed:

Aug. 25, 2014

Hydroxybenzamide derivatives and their use as inhibitors of hsp90

Applicant:

Astex Therapeutics Ltd., Cambridge, GB;

Inventors:

Gianni Chessari, Cambridge, GB;

Miles Stuart Congreve, Cambridge, GB;

Martyn Frederickson, Cambridge, GB;

Christopher William Murray, Cambridge, GB;

Eva Figueroa Navarro, Cambridge, GB;

Alison Jo-Anne Woolford, Cambridge, GB;

Maria Grazia Carr, Luton, GB;

Robert Downham, Cambridge, GB;

Michael Alistair O'Brien, Hertz, GB;

Theresa Rachel Phillips, Macclesfield, GB;

Andrew James Woodhead, Cambridge, GB;

Assignee:

Astex Therapeutics Ltd., Cambridge, GB;

Attorneys:

Vedder Price P.C.

Thomas J. Kowalski

Deborah L. Lu

Primary Examiner:

Nyeemah A Grazier

Int. Cl.
CPC ...
A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/445 (2006.01); A61K 31/4035 (2006.01); C07D 401/12 (2006.01); C07D 209/08 (2006.01); C07D 209/44 (2006.01); C07D 215/08 (2006.01); C07D 217/06 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 491/08 (2006.01); C07D 491/10 (2006.01); C07C 65/21 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07C 65/21 (2013.01); C07D 209/08 (2013.01); C07D 209/44 (2013.01); C07D 215/08 (2013.01); C07D 217/06 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 491/08 (2013.01); C07D 491/10 (2013.01);
Abstract

The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein Ris hydroxy or hydrogen; Ris hydroxy; methoxy or hydrogen; provided that at least one of Rand Ris hydroxy; Ris selected from hydrogen; halogen; cyano; optionally substituted Chydrocarbyl and optionally substituted Chydrocarbyloxy; Ris selected from hydrogen; a group —(O)—Rwhere n is 0 or 1 and Ris an optionally substituted acyclic Chydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-Chydrocarbyl-amino; or Rand Rtogether form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NRRforms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

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