The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Nov. 05, 2014
Shanghai Jiaotong University School of Medicine, Huangpu District, Shanghai, CN;
Yang Lu, Shanghai, CN;
Jianhua Liu, Shanghai, CN;
Shuangqi Tang, Shanghai, CN;
Hongzhuan Chen, Shanghai, CN;
SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE, Huangpu District, Shanghai, CN;
Abstract
A stearoyl amino acid salt having a structural formula of the general formula (I), wherein Ris H or an aromatic base capable of being substituted by one or more substituents, or a Cstraight chain or an alkyl with a branched chain, the substituent being an alcoholic hydroxyl group or a phenolic hydroxyl group; and Ris a Csaturated or unsaturated aliphatic group. Also provided are methods of preparing the stearoyl amino acid salt, and methods of using the stearoyl amino acid salt. Compared to a prototype drug stearoyl amino acid, the stearoyl amino acid salt described herein has excellent physicochemical properties, good stability, high relative bioavailability, a strong drug effect and a high safety factor. It is thus expected to become a candidate for clinical treatment of neurodegenerative diseases and acute brain injury, and a clinical drug for weight loss, thus having broad application prospects.