The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Jul. 16, 2013
Dicerna Pharmaceuticals, Inc., Watertown, MA (US);
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Tomoyuki Naoi, Tokyo, JP;
Takeshi Kuboyama, Tokyo, JP;
Junichi Enokizono, Shizuoka, JP;
Toshihiko Ishii, Shizuoka, JP;
Akihiro Tokunaga, Shuzuoka, JP;
Kentarou Hatanaka, Tokyo, JP;
KYOWA HAKKO KIRIN CO., LTD., Tokyo, JP;
DICERNA PHARMACEUTICALS, INC., Watertown, MA (US);
Abstract
The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and a cationic lipid represented by the following formula (I): wherein