The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Jun. 06, 2016
Applicant:
Astex Pharmaceuticals, Inc., Pleasanton, CA (US);
Inventors:
Rajashree Joshi-Hangal, Pleasanton, CA (US);
Chunlin Tang, Walnut Creek, CA (US);
Sanjeev Redkar, Hayward, CA (US);
Harish Ravivarapu, Pleasanton, CA (US);
Assignee:
ASTEX PHARMACEUTICALS, INC., Pleasanton, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7084 (2006.01); A61K 31/706 (2006.01); A61K 31/7056 (2006.01); A61K 31/7064 (2006.01); A61K 31/7052 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/20 (2006.01); A61K 9/19 (2006.01); A61K 31/708 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7084 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 31/706 (2013.01); A61K 31/708 (2013.01); A61K 31/7052 (2013.01); A61K 31/7056 (2013.01); A61K 31/7064 (2013.01); A61K 47/10 (2013.01); A61K 47/20 (2013.01);
Abstract
The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives. Methods of treating one or more myelodysplastic syndromes, leukemia, or solid tumours using the formulations are described.