The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2018
Filed:
Oct. 01, 2009
Bile acids and biguanides as protease inhibitors for preserving the integrity of peptides in the gut
Applicants:
Roger R. C. New, London, GB;
Glen Travers, London, GB;
Inventors:
Roger R. C. New, London, GB;
Glen Travers, London, GB;
Assignee:
AXCESS LIMITED, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 31/575 (2006.01); A61K 31/155 (2006.01); A61K 45/06 (2006.01); A61K 9/20 (2006.01); A61K 9/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/575 (2013.01); A61K 31/155 (2013.01); A61K 38/12 (2013.01); A61K 45/06 (2013.01); A61K 9/2013 (2013.01); A61K 9/28 (2013.01);
Abstract
This invention relates to methods of preserving the integrity of peptides in the gut. In particular it concerns the use of certain compounds as inhibitors of gut proteases. Compounds identified as having gut protease inhibitory activity are biguanides, certain bile acids and pharmaceutically acceptable salts of these compounds. This activity makes these compounds useful for co-administration with prophylactic or therapeutic peptides. This invention relates to methods of inhibiting gut proteases and peptide formulations comprising these gut protease inhibitor.