The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 13, 2018

Filed:

Sep. 10, 2012
Applicants:

Todd M. Brusko, Gainesville, FL (US);

Benjamin G. Keselowsky, Gainesville, FL (US);

Judit Cserny, Gainesville, FL (US);

Inventors:

Todd M. Brusko, Gainesville, FL (US);

Benjamin G. Keselowsky, Gainesville, FL (US);

Judit Cserny, Gainesville, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 31/436 (2006.01); A61K 9/51 (2006.01); A61K 38/20 (2006.01); A61K 38/28 (2006.01); A61K 38/51 (2006.01); A61K 31/453 (2006.01); A61K 31/4704 (2006.01);
U.S. Cl.
CPC ...
A61K 31/436 (2013.01); A61K 9/5153 (2013.01); A61K 31/453 (2013.01); A61K 31/4704 (2013.01); A61K 38/2013 (2013.01); A61K 38/28 (2013.01); A61K 38/51 (2013.01); A61K 47/48776 (2013.01); A61K 47/48915 (2013.01); C12Y 401/01015 (2013.01);
Abstract

The present invention provides nanoparticle-coupled tolerogenic Treg cell therapy for treatment of immune and/or autoimmune disorders. In certain specific embodiments, the present invention can be used in the prevention and/or treatment of autoimmune diseases including, but not limited to, type 1 diabetes, lupus erythematosus (SLE), multiple sclerosis (MS), inflammatory bowel disease (IBD), rheumatoid arthritis, oophoritis, and autoimmune pathology associated with Graft versus Host Disease (GvHD) following hematopoietic stem cell transplantation.


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