The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Feb. 10, 2014
Cornell University, Ithaca, NY (US);
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (US);
University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Northeastern University, Boston, MA (US);
Steven A. Soper, Baton Rouge, LA (US);
Francis Barany, New York, NY (US);
George Grills, Trumansburg, NY (US);
Robin McCarley, Prairieville, LA (US);
Collin J. McKinney, Durham, NC (US);
Dorel Moldovan, Baton Rouge, LA (US);
Michael C. Murphy, Baton Rouge, LA (US);
Dimitris Nikitopoulos, Baton Rouge, LA (US);
Sunggook Park, Baton Rouge, LA (US);
Elizabeth J. Podlaha-Murphy, West Roxbury, MA (US);
Cornell University, Ithaca, NY (US);
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Northeastern University, Boston, MA (US);
Board of Supervisors of Louisiana State University and Agriculture and Mechanical College, Baton Rouge, LA (US);
Abstract
The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.