The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Apr. 18, 2013
Applicant:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Inventors:
Mustafa N. Yazicioglu, Cayirova-Kocaeli, TR;
Federico Mingozzi, Paris, FR;
Xavier Anguela, Philadelphia, PA (US);
Katherine A. High, Merion Station, PA (US);
Assignee:
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 48/00 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 48/00 (2013.01); C07K 14/005 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial transgenes. AAV variants are provided which exhibit increased transduction efficiency when compared to AAV serotypes (e.g., AAV1, AAV2, AAV8, AAV-rh74), which lack the modifications disclosed herein. Such improved vectors are useful for transduction of a variety of tissues.