The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Jun. 16, 2015
Bristol-myers Squibb Company, Princeton, NJ (US);
Domantis Limited, Brentford, Middlesex, GB;
Murray McKinnon, Washington Crossing, PA (US);
Steven G. Nadler, Princeton, NJ (US);
Suzanne J. Suchard, Wilmington, DE (US);
Brendan Classon, Princeton, NJ (US);
Steve Holmes, Cambridge, GB;
Olga Ignatovich, Cambridge, GB;
Christopher Plummer, Romsey, GB;
Steve Grant, Swaffham Prior, GB;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Domantis Limited, Brentford, Middlesex, GB;
Abstract
Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.