The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 06, 2018

Filed:

Feb. 05, 2016
Applicants:

Incyte Holdings Corporation, Wilmington, DE (US);

Incyte Corporation, Wilmington, DE (US);

Inventors:

Jiacheng Zhou, Newark, DE (US);

Pingli Liu, Newark, DE (US);

Qiyan Lin, Newark, DE (US);

Brian W. Metcalf, Moraga, CA (US);

David Meloni, Bear, DE (US);

Yongchun Pan, Newark, DE (US);

Michael Xia, Wilmington, DE (US);

Mei Li, Newark, DE (US);

Tai-Yuen Yue, Hockessin, DE (US);

James D. Rodgers, Landenberg, PA (US);

Haisheng Wang, Hockessin, DE (US);

Assignees:

Incyte Corporation, Wilmington, DE (US);

Incyte Holdings Corporation, Wilmington, DE (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 231/10 (2006.01); C07F 7/18 (2006.01); C07F 7/10 (2006.01); C07F 5/02 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07F 5/025 (2013.01); C07F 7/083 (2013.01); C07F 7/10 (2013.01); C07F 7/1892 (2013.01); Y02P 20/55 (2015.11);
Abstract

The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.


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