The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Dec. 15, 2014
Applicant:
Gilead Sciences, Inc., Foster City, CA (US);
Inventor:
Gregory Notte, San Mateo, CA (US);
Assignee:
GILEAD SCIENCES, INC., Foster City, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/444 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); C07D 487/04 (2006.01); C07D 491/107 (2006.01); A61K 31/435 (2006.01); A61K 31/4985 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/435 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); C07D 487/04 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01);
Abstract
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.