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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9908845 B1

PDFFull Text
Date of Patent:
Mar. 06, 2018

Filed:

Sep. 05, 2014

Aryl ethers and uses thereof

Applicant:

Peloton Therapeutics, Inc., Dallas, TX (US);

Inventors:

Darryl David Dixon, Dallas, TX (US);

Jonas Grina, Coppell, TX (US);

John A. Josey, Dallas, TX (US);

James P. Rizzi, Irving, TX (US);

Stephen T. Schlachter, Dallas, TX (US);

Eli M. Wallace, Richardson, TX (US);

Bin Wang, Dallas, TX (US);

Paul Wehn, Dallas, TX (US);

Rui Xu, Dallas, TX (US);

Hanbiao Yang, Coppell, TX (US);

Assignee:

PELOTON THERAPEUTICS, INC., Dallas, TX (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Theodore R West

Int. Cl.
CPC ...
C07C 317/22 (2006.01); C07C 43/225 (2006.01); C07C 43/23 (2006.01); A61K 31/09 (2006.01); A61K 31/10 (2006.01); C07C 311/29 (2006.01); C07C 43/285 (2006.01); C07C 43/205 (2006.01); C07C 43/263 (2006.01); C07C 255/54 (2006.01); C07C 255/56 (2006.01); C07C 205/22 (2006.01); C07C 313/06 (2006.01); C07C 317/24 (2006.01); C07C 317/32 (2006.01); C07C 317/34 (2006.01); C07C 317/36 (2006.01); C07C 317/40 (2006.01); C07C 317/42 (2006.01); C07C 317/44 (2006.01); C07C 317/46 (2006.01); C07C 317/48 (2006.01); C07C 323/22 (2006.01); C07C 381/10 (2006.01); C07D 213/89 (2006.01); C07D 231/56 (2006.01); C07D 213/65 (2006.01); C07D 213/85 (2006.01);
U.S. Cl.
CPC ...
C07C 311/29 (2013.01); A61K 31/09 (2013.01); A61K 31/10 (2013.01); C07C 43/205 (2013.01); C07C 43/225 (2013.01); C07C 43/23 (2013.01); C07C 43/263 (2013.01); C07C 43/285 (2013.01); C07C 205/22 (2013.01); C07C 255/54 (2013.01); C07C 255/56 (2013.01); C07C 313/06 (2013.01); C07C 317/22 (2013.01); C07C 317/24 (2013.01); C07C 317/32 (2013.01); C07C 317/34 (2013.01); C07C 317/36 (2013.01); C07C 317/40 (2013.01); C07C 317/42 (2013.01); C07C 317/44 (2013.01); C07C 317/46 (2013.01); C07C 317/48 (2013.01); C07C 323/22 (2013.01); C07C 381/10 (2013.01); C07D 213/65 (2013.01); C07D 213/85 (2013.01); C07D 213/89 (2013.01); C07D 231/56 (2013.01); C07C 2602/04 (2017.05); C07C 2602/08 (2017.05); C07C 2602/10 (2017.05); C07C 2603/94 (2017.05);
Abstract

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.

Find Patent Forward Citations

Dixon, Darryl. (2018). Aryl ethers and uses thereof (U.S. Patent No. 9908845). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9908845

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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