The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 06, 2018

Filed:

Dec. 15, 2016
Applicant:

Durect Corporation, Cupertino, CA (US);

Inventors:

Su Il Yum, Los Altos, CA (US);

Wendy Chao, San Jose, CA (US);

Huey-Ching Su, San Jose, CA (US);

Roger Fu, Saratoga, CA (US);

Michael S. Zamloot, Austin, TX (US);

Karl Bratin, Groton, CT (US);

Ravi M. Shanker, Groton, CT (US);

Assignee:

Durect Corporation, Cupertino, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 31/4458 (2006.01); A61K 31/137 (2006.01); A61K 47/02 (2006.01); A61K 47/14 (2017.01); A61K 47/26 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 47/02 (2013.01); A61K 31/485 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01);
Abstract

The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.


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