The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Jul. 15, 2016
Applicant:
Silk Technologies, Ltd., Plymouth, MN (US);
Inventors:
Brian D. Lawrence, Minneapolis, MN (US);
David W. Infanger, Maple Grove, MN (US);
Assignee:
Silk Technologies, Ltd., Plymouth, MN (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/39 (2006.01); A61K 35/64 (2015.01); A23L 2/66 (2006.01); C07K 14/78 (2006.01); A23L 33/17 (2016.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/39 (2013.01); A23L 2/66 (2013.01); A23L 33/17 (2016.08); A61K 35/64 (2013.01); A61K 45/06 (2013.01); C07K 14/78 (2013.01); A23V 2002/00 (2013.01);
Abstract
The invention provides a protein composition derived from silk fibroin, which composition possesses enhanced solubility and stability in aqueous solutions. The primary amino acid sequence of native fibroin is modified in the SDP such that cysteine disulfide bonds between the fibroin heavy and fibroin light protein chains are reduced or eliminated. Additionally, the composition can have a serine content that is reduced by greater than 40% compared to native fibroin protein, and the average molecular weight of the SDP is less than about 100 kDa.