The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Jun. 22, 2012
Abhijit S. Bapat, Delhi, IN;
Gauthami Mahesh, East Delhi, IN;
Rajesh S. Gokhale, New Delhi, IN;
Sayali S. Shah, East Delhi, IN;
Shiladitya Sengupta, Waltham, MA (US);
Sudhanand Prasad, Uttar Pradesh, IN;
Sumana Ghosh, New Delhi, IN;
Suresh R. Chawrai, Delhi, IN;
Nidhi Arora, New Delhi, IN;
D. Sreedhar Reddy, Andhra Pradesh, IN;
Mallika Mishra, Ghaziabad, IN;
Kirti Bajaj, Haryana, IN;
Abhijit S. Bapat, Delhi, IN;
Gauthami Mahesh, East Delhi, IN;
Rajesh S. Gokhale, New Delhi, IN;
Sayali S. Shah, East Delhi, IN;
Shiladitya Sengupta, Waltham, MA (US);
Sudhanand Prasad, Uttar Pradesh, IN;
Sumana Ghosh, New Delhi, IN;
Suresh R. Chawrai, Delhi, IN;
Nidhi Arora, New Delhi, IN;
D. Sreedhar Reddy, Andhra Pradesh, IN;
Mallika Mishra, Ghaziabad, IN;
Kirti Bajaj, Haryana, IN;
VYOME BIOSCIENCES PVT. LTD., Delhi, IN;
Abstract
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)-X-(L); (ii) [(AFA)-X]-L; (iii) AFA-[X-(L)]; or (iv) (AFA)-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m' is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.