The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2018
Filed:
Apr. 02, 2014
The Doshisha, Kyoto, JP;
National Center for Geriatrics and Gerontology, Aichi, JP;
Tomohiro Miyasaka, Kyoto, JP;
Hachiro Sugimoto, Kyoto, JP;
Rie Tokizane, Hyogo, JP;
Yuki Shinzaki, Kyoto, JP;
Yohei Oe, Kyoto, JP;
Tetsuo Ota, Kyoto, JP;
Akihiko Takashima, Saitama, JP;
Yoshiyuki Soeda, Fukushima, JP;
Yasuo Ihara, Kyoto, JP;
Yoshikazu Inoue, Kyoto, JP;
THE DOSHISHA, Kyoto, JP;
National Center for Geriatrics and Gerontology, Aichi, JP;
Abstract
A tau aggregation inhibitor can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof. The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).