The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 06, 2018

Filed:

Sep. 04, 2015
Applicants:

University of Washington, Seattle, WA (US);

Regents of the University of Minnesota, Minneapolis, MN (US);

Inventors:

Krzysztof Palczewski, Bellevue, WA (US);

Shalesh Kaushal, Gainesville, FL (US);

Vladimir Kuksa, Seattle, WA (US);

Syed M. Noorwez, Gainesville, FL (US);

Assignees:

UNIVERSITY OF WASHINGTON, Seattle, WA (US);

REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/11 (2006.01); A61K 31/07 (2006.01); A61K 38/17 (2006.01); A61K 31/382 (2006.01); A61K 31/435 (2006.01); A61K 31/695 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/11 (2013.01); A61K 9/0048 (2013.01); A61K 31/07 (2013.01); A61K 31/382 (2013.01); A61K 31/435 (2013.01); A61K 31/695 (2013.01); A61K 38/1709 (2013.01); Y10S 514/912 (2013.01);
Abstract

Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.


Find Patent Forward Citations

Loading…