The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Feb. 13, 2012
Marla C. Dubinsky, Los Angeles, CA (US);
Dermot P. Mcgovern, Los Angeles, CA (US);
Jerome I. Rotter, Los Angeles, CA (US);
Stephan R. Targan, Santa Monica, CA (US);
Marla C. Dubinsky, Los Angeles, CA (US);
Dermot P. McGovern, Los Angeles, CA (US);
Jerome I. Rotter, Los Angeles, CA (US);
Stephan R. Targan, Santa Monica, CA (US);
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Abstract
The present invention relates to methods of predicting susceptibility to a severe form of Crohn's disease in an individual by determining the presence or absence of one or more risk variants. In one embodiment, the risk variants comprise a combination of genetic risk variants and clinical risk factors. In another embodiment, the genetic risk variants are at the IL12B genetic locus. In another embodiment, the severe form of Crohn's disease is characterized by a rapid progression to a condition requiring surgery for treatment.