The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Jul. 21, 2014
Integral Molecular, Inc., Philadelphia, PA (US);
Blood Systems Research Institute, San Francisco, CA (US);
Benjamin Doranz, Philadelphia, PA (US);
Kimberly-Anne Mattia, Philadelphia, PA (US);
Kristen Kahle, Philadelphia, PA (US);
Graham Simmons, San Francisco, CA (US);
Rachel Hua-Ning Fong, Philadelphia, PA (US);
Soma Banik Banerjee, Philadelphia, PA (US);
INTEGRAL MOLECULAR, INC., Philadelphia, PA (US);
BLOOD SYSTEMS RESEARCH INSTITUTE, San Francisco, CA (US);
Abstract
Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.