The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Mar. 14, 2013
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Scott A. Hilderbrand, Swampscott, MA (US);
Neal K. Devaraj, Boston, MA (US);
Ralph Weissleder, Peabody, MA (US);
Mark R. Karver, Chicago, IL (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/08 (2006.01); C07D 403/12 (2006.01); C07D 401/04 (2006.01); A61K 31/4015 (2006.01);
U.S. Cl.
CPC ...
C07D 257/08 (2013.01); C07D 401/04 (2013.01); C07D 403/12 (2013.01);
Abstract
The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a 'payload' to a ligand bound to a biological target.